Hugo BLONS, new PhD student, joins the team TERA

Physics of solute transport in microvascular networks of the brain

Cerebral blood microcirculation allows the supply of oxygen to neurons and the elimination of their metabolic waste. The architecture of microvascular networks leads to a heterogeneous distribution of blood flow and transit time, the consequences of which on the pathophysiology of the brain are beginning to be discovered [1].

As part of a collaboration between Geosciences Rennes and the Porous and Biological Media team of the Institute of Fluid Mechanics of Toulouse a new model describing the dynamics of solute transport in cerebral microvascular networks, was proposed. This new study framework has notably highlighted anomalous transport of solutes linked to microvascular networks and the appearance of critical areas, low in oxygen or rich in waste, in case of decreased oxygen supply [2].

The doctoral project of Hugo BLONS, is part of the continuation of the research collaboration between GR and IMFT. Based on the first results obtained, it will be necessary to study the possible quantitative relationships existing between the network structure and microvascular dysfunctions of the brain, exploring the impact of different network architectures on the emergence of critical areas.

[1]. Jespersen, S. N. & Østergaard, L. The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism. Journal of Cerebral Blood Flow & Metabolism, 32, 264–277 (2012).
[2]. Goirand, F., Le Borgne, T., & Lorthois, S. Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction. Nature communications,12(1), 7295 (2021).